Curvature Dependence of Nuclear Rupture Frequency Revealed by AFM Force Spectroscopy
نویسندگان
چکیده
منابع مشابه
Accurate, explicit formulae for higher harmonic force spectroscopy by frequency modulation-AFM
The nonlinear interaction between an AFM tip and a sample gives rise to oscillations of the cantilever at integral multiples (harmonics) of the fundamental resonance frequency. The higher order harmonics have long been recognized to hold invaluable information on short range interactions but their utilization has thus far been relatively limited due to theoretical and experimental complexities....
متن کاملSingle-Molecule Force Spectroscopy on Poly(acrylic acid) by AFM
The mechanical properties of poly(acrylic acid) (PAA) were investigated on the molecular scale by using AFM. PAA was adsorbed onto a glass substrate and then picked up at one point of the chain with the AFM tip and stretched. The deformation of single PAA chains under tension was measured and modeled by a modified freely-joint-chain model. The length distribution of loops and tails of adsorbed ...
متن کاملSingle - Molecule Force Spectroscopy on Xanthan by AFM
316 Ó WILEY-VCH Verlag GmbH, D-69469 Weinheim, 1998 0935-9648/98/0403-0316 $ 17.50+.50/0 Adv. Mater. 1998, 3, No. 4 [5] a) A. D. Firouzi, D. Kumar, L. M. Bull, T. Besier, P. Sieger, Q. Huo, S. A. Walker, J. A. Zasadzinski, C. Glinka, J. Nicol, D. Margolese, G. D. Stucky, B. F. Chmelka, Science 1995, 267, 1138. b) A. Monnier, F. Schüth, Q. Huo, D. Kumar, D. Margolese, R. S. Maxwell, G. D. Stucky...
متن کاملStatistical Analysis of Single-Molecule AFM Force Spectroscopy Curves
We develop a statistical framework for the quantitative characterization and analysis of force-extension curves obtained from single-molecule force spectroscopy (SMFS) measurements. We apply this methodology to force-extension data obtained for elastinlike polypeptides (ELPs) with precisely engineered molecular architectures, where we demonstrate that our approach enables SMFS to be used to stu...
متن کاملSingle-protein Afm-based Force Spectroscopy Nyu-csmr
The recently developed single molecule force spectroscopy enables the detailed study of the mechanisms of protein unfolding and refolding under a stretching force. It has revealed many signatures of complexity of the underlying energy landscape that were previously overlooked in bulk experiments. For example, the broad distribution of unfolding times of the protein ubiquitin has been suggestive...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biophysical Journal
سال: 2018
ISSN: 0006-3495
DOI: 10.1016/j.bpj.2017.11.3534